Metabolism underpins life by driving critical functions such as bioenergetic reactions, the synthesis of essential macromolecules, detoxification, and the maintenance of homeostasis. These processes are fundamental to cellular and organismal viability. However, the biochemical reactions and enzymes are not homogeneously distributed in a cell, but rather compartmentalized in organelles and their specialized sub-domains. The shape, distribution, interaction, and overall organization of organelles in specialized tissues vary at different spatial and temporal scales,...
