Metabolic Biology

Ronald M. Krauss, M.D., is Senior Scientist and Dolores Jordan Endowed Chair at Children’s Hospital Oakland Research Institute, Professor of Medicine at UCSF, and Adjunct Professor of Nutritional Sciences at UC Berkeley. He is a member of the American Society for Clinical Investigation, a Fellow of the American Society of Nutrition and the American Heart Association (AHA), and a Distinguished Fellow of the International Atherosclerosis Society. He has served on the U.S. National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High...

Research in the Lewis laboratory focuses on mitochondria, the dynamic, double membrane bound organelle that is essential for oxidative phosphorylation. Specifically, our area of study is mitochondrial DNA (mtDNA) synthesis and distribution within human cells. Mitochondria maintain their own multi-copy genome independent of the nucleus; the goals of my work are to understand how mtDNA copy number is regulated within and across cell cycles, and how the disruption of these pathways impinges on mtDNA integrity, cellular metabolism, and ultimately human health. Using...