Molecular Toxicology

metabolism, obesity, adipose tissue, epigenetics

Research Description

The Napoli lab studies regulation of the metabolon that generates the autocoid all-trans-retinoic acid (atRA) from retinol (vitamin A), and the function of atRA in in modulating intermediary metabolism (energy balance), diabesity, adipogenesis, bone health (osteoporosis) and blood glucose control. We use a combination of analytical chemistry, bioimaging, biochemistry and molecular and cell biology to determine the physiological effects of atRA.

Diabesity

We have individually knocked out two of the retinol dehydrogenases (Rdh) that catalyze the first reaction in...

metabolism, obesity, adipose tissue, brown fat, thermogenesis, tissue engineering, diabetes, fatty acid transport, fatty acid, stem cells, microphysiological systems, lipid nanoparticles, liver disease