Dr. King’s research focuses on the functions of and the dietary requirements for zinc. Early in her career, Dr. King developed the use of stable isotopes to study zinc metabolism in humans. Today, those techniques are widely used around the world to identify and treat the zinc deficiency, the most prevalent nutrient deficiency worldwide. Currently, about 700,000 children die each year due to zinc deficiency. Using novel biomarkers of zinc nutrition and the isotopic techniques developed in her lab, Dr. King is currently testing the efficacy of various programs to reduce...
The Napoli lab studies regulation of the metabolon that generates the autocoid all-trans-retinoic acid (atRA) from retinol (vitamin A), and the function of atRA in in modulating intermediary metabolism (energy balance), diabesity, adipogenesis, bone health (osteoporosis) and blood glucose control. We use a combination of analytical chemistry, bioimaging, biochemistry and molecular and cell biology to determine the physiological effects of atRA.
Diabesity
We have individually knocked out two of the retinol dehydrogenases (Rdh) that catalyze the first reaction in...
